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Drug Development Despite the multiple benefits of GHS and the fact that they are safe, (no serious general pharmaco-pathological effects at dose levels showing GH-releasing activity have ever been reported), extensive basic research by university and other public sector scientists undoubtedly thwarted commercial development due to loss of patent protection and other competitive factors

Research published in JCI Insight describes tirzepatide as an "imbalanced and biased" dual agonist, meaning it shows equal affinity for the GIP receptor compared to native GIP but approximately 5-fold weaker affinity for the GLP-1 receptor compared to native GLP-1

Koppula et al., 2017

Moreover, while supporting thyroid function, an intake of iodized salt not exceeding 5 g per day does not increase the risk of hypertension and related cardiovascular diseases (CVD), and is consistent with CVD prevention strategies avoiding excessive sodium intake